Apamea

Apamea, on the right bank of the Orontes River, was a treasure city and stud-depot of the Seleucid kings, and was the capital of Apamene. (Stephanus of Byzantium s. v.; Strabo xvi. p. 752; Ptolemy v. 15. § 19; Festus Avienus, v. 1083; Anton. Itin.; Hierocles). Its site is found about 55 km (34 mi) to the northwest of Hama, Syria, overlooking the Ghab valley. Previously known as Pharmake, it was fortified and enlarged by Seleucus I Nicator in 300 BC, who so named it after his Bactrian wife, Apama – not his mother, as Stephanus asserts (compare Strabo, p. 578). In pursuance of his policy of Hellenizing Syria, it bore the Macedonian name of Pella – Wikipedia

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